Il1b-Luc-2A-EGFP

Background : C57BL/6Smoc

Catalog : NM-KI-00010

Strain Name : C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc

Gene Summary

Gene Name

Model Description

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.

Validation Data

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Fig1. IL1β reporter gene expression in the mice was monitored through noninvasive molecular imaging. IL1 β  in the mouse body was activated through LPS  treatment.

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Fig2. Analysis of EGFP expresssion in PBMC by FACS. The homozygous KI mouse expresses EGFP in  F4/80+ macrophages in peripheral blood.

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Fig3. Analysis of EGFP expresssion in the spleen by FACS. The homozygous KI mouse expresses EGFP in F4/80+ macrophages in the spleen.

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Fig4. Analysis of EGFP expresssion in the liver by FACS. The homozygous KI mouse expresses EGFP in F4/80+ macrophages in the liver.


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