Jak2-Flox-V617F/Vav1-Cre-Tg

Gene Summary

Gene Name

Strain State :
Repository Live

Model Description

The Jak2-Flox-V617F was crossed with Vav1-Cre-Tg to generate Jak2-Flox-V617F/Vav1-Cre-Tg mice.

Validation Data

Table 1. Blood routine test results of of HE/HE Jak2-Flox-V617F/Vav1-Cre-Tg mice (8 weeks）(Data are presented as mean and ± SEM).

Table 2. Blood routine test results of of HE/HE Jak2-Flox-V617F/Vav1-Cre-Tg mice (10 weeks）(Data are presented as mean and ± SEM).

Table 3. Blood routine test results of of HE/HE Jak2-Flox-V617F/Vav1-Cre-Tg mice (14 weeks）(Data are presented as mean and ± SEM).

Table 4. Blood routine test results of of HE/HE Jak2-Flox-V617F/Vav1-Cre-Tg mice (16 weeks）(Data are presented as mean and ± SEM).

Fig 1. Alopecia phenotype observed in HE/HE Jak2-Flox-V617F/Vav1-Cre-Tg mice.

Fig 2. Photographs (A) and Spleen weight (B) of spleen of 27-28 weeks old C57BL/6 and HE/HE Jak2-Flox-V617F/Vav1-Cre-Tg(JAK2^VF/+) mice.

Fig 3. Representative images of H&E staining of bone marrow, spleen, and liver in 28-week-old HE/HE Jak2-Flox-V617F/Vav1-Cre-Tg(JAK2^VF/+) mice.

Spleen structure is destroyed and significantly enlarged, with a marked reduction in white pulp cells, a substantial increase in erythroid precursor cells, and a notable increase in megakaryocytes. In the bone marrow, there is megakaryocyte hyperplasia and an increase in cell clusters. In liver tissue, megakaryocytes are frequently observed, indicating extramedullary hematopoiesis(n=3).