Rag-2
胚胎冻存
Figure 1. Generation strategy of Rag2 gene knockout mice.
Figure 2 Splenocytes cells of C57BL/6J, NOD-SCID, Rag1-/-, and Rag2-/- mice were isolated. Fractions of T and B cells were characterized using flow cytometry.
Figure3. Complete deletion of T and B cells in the blood of Rag1-KO/ Rag2-KO mice.
(A) The peripheral blood samples of C57BL/6, Rag1-KO and Rag2-KO mice were collected to analyze their compositions of T, B and NK cells by FACS.(B) Statistical analysis of sorted cells.
Figure4. Complete deletion of T and B cells in the spleen of Rag1-KO/ Rag2-KO mice.
(A) The splenocytes of C57BL/6, Rag1-KO and Rag2-KO mice were collected to analyze their compositions of T, B and NK cells by FACS.(B) Statistical analysis of sorted cells.
Figure5. Complete deletion of T and B cells in the thymus gland of Rag1-KO/ Rag2-KO mice.
(A) The thymocyte of C57BL/6, Rag1-KO and Rag2-KO mice were collected to analyze their compositions of T, B and NK cells by FACS.(B) Statistical analysis of sorted cells.
Figure6. EGFP expression of Rag2 knockout mice was detected.
The results showed that there were EGFP-positive cells in the thymus and spleen of Rag2 KO mice, but the EGFP-positive cells were both CD4-negative and CD8-negative cells.
Figure7.The establishment of tumor models using A549 lung cancer cells is more effective in Rag1-/- or Rag2-/- mice.
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