Model Description
Studies have shown that Cre expression in mouse models may also exert toxic side effects, such as infertility and decreased viability. This is especially true for the Cre homozygous mice of certain strains. An excessively high Cre activity may induce the recombination at unknown loxP sites in the genome, thus triggering knockout or translocation and subsequently affecting mouse survival. In addition, in the Cre transgenic strains obtained by microinjection, the insertion of Cre gene may interfere with the functions of certain important endogenous genes.
<span style=";font-family:等线;font-size:15px"></span>
