hTIM3

Background : C57BL/6Smoc

Catalog : NM-HU-00054

Strain Name :

C57BL/6Smoc-Havcr2em1(hHAVCR2)/Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Tim3 gene was replaced by human TIM3 gene .

Validation Data

image.png

Fig1. Detection of TIM3 expression by PCR. 

Wild type: only one band at 248 bp with primers F2/R2(mTim3);

Homozygous: only one band at 328 bp with primers F1/R1(hTIM3); 

Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.pngFig2. Analysis of hTIM3 expression on stimulated CD4+ and CD8+  T cells in hTIM-3 knockin mice by FACS. (Completed in cooperation with CrownBio)


image.png

Fig3. Analysis of Tim-3 expression at very low levels on naive T cells by FACS.

image.pngFig4. Analysis of hTIM3 expression at high levels on CD11b+ myeloid cells by FACS.

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