What is an inbred strain?

Gene Summary

Gene Name

Model Description

<p style="text-align: justify;">An animal strain established by 20 (or more) consecutive generations of mating among siblings (or via mating between a parental generation and a progeny generation). The inbreeding coefficient of the stain should be greater than 99%, and all individuals in the strain should be traced back to a common pair of ancestors. <p style="text-align: justify;">Characteristics: The genetic background is uniform and the experimental results are consistent. However, due to inbreeding depression and low viability, an inbred strain has a low number of litters and a more stringent demand for the breeding environment and nutritions. <p style="text-align: justify;">The commonly used C57BL/6, Balb/c, and FVB all belong to inbred strains. <br>
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